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Speech research — first_speech_report

journal/autism-evidence/2026-08-29-speech-research-first-speech-report.md · updated 2026-08-29

Speech research — first_speech_report

FIRST SPEECH REPORT

What vitamins, minerals, supplements, deficiencies, or biological interventions have been studied for speech, language, or communication outcomes in autistic children?

Grades per intervention x track. Supporting studies are real PMIDs from this database.

STRONGEST EVIDENCE

None at this level.

MODERATE EVIDENCE

vitamin B6 — grade B (Supplementing WITHOUT deficiency; 5 studies, 1 RCT, speech directly measured in 5)

  • PMID:19393386 — [Treatment of a serious autistic disorder in a child with Naltrexone i (2009)
  • PMID:21729335 — Autism. (2010)
  • PMID:19450315 — Autism. (2008)
  • PMID:28538871 — What do Cochrane systematic reviews say about interventions for autism (2017) magnesium — grade B (Supplementing WITHOUT deficiency; 4 studies, 1 RCT, speech directly measured in 4)
  • PMID:21729335 — Autism. (2010)
  • PMID:19450315 — Autism. (2008)
  • PMID:28538871 — What do Cochrane systematic reviews say about interventions for autism (2017)
  • PMID:9261669 — High-dose pyridoxine and magnesium administration in children with aut (1997) essential fatty acids — grade B (Supplementing WITHOUT deficiency; 12 studies, 2 RCT, speech directly measured in 12)
  • PMID:32088673 — Results of a Consumer Survey on the Effectiveness of a Nutritional Ble (2021)
  • PMID:21729335 — Autism. (2010)
  • PMID:19450315 — Autism. (2008)
  • PMID:33599431 — The effect of omega-3 fatty acids supplementation on social and behavi (2021) vitamin D — grade B (Supplementing WITHOUT deficiency; 5 studies, 1 RCT, speech directly measured in 5)
  • PMID:28626020 — Lack of effect of vitamin D (2017)
  • PMID:40521363 — Omega-3 fatty acids: multi-target mechanisms and therapeutic applicati (2025)
  • PMID:37864660 — Biological Pathways Associated with Vitamins in Autism Spectrum Disord (2023)
  • PMID:40259156 — Nutritional Approaches in Autism Spectrum Disorder: A Scoping Review. (2025) folinic acid — grade B (Supplementing WITHOUT deficiency; 3 studies, 2 RCT, speech directly measured in 3)
  • PMID:27752075 — Folinic acid improves verbal communication in children with autism and (2018)
  • PMID:22230883 — Cerebral folate receptor autoantibodies in autism spectrum disorder. (2013)
  • PMID:32387472 — Folinic acid improves the score of Autism in the EFFET placebo-control (2020) iron — grade B (Supplementing WITHOUT deficiency; 2 studies, 1 RCT, speech directly measured in 2)
  • PMID:38739382 — Effect of Low-Dose Iron Supplementation on Early Development in Breast (2024)
  • PMID:28407219 — Multiple-micronutrient supplementation for women during pregnancy. (2017)

PRELIMINARY EVIDENCE

vitamin B12 — grade C (Supplementing WITHOUT deficiency; 3 studies, 0 RCT, speech directly measured in 3)

  • PMID:27338456 — Efficacy of Folic Acid Supplementation in Autistic Children Participat (2016)
  • PMID:19393386 — [Treatment of a serious autistic disorder in a child with Naltrexone i (2009)
  • PMID:34442428 — The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Dis (2021) folate — grade C (Supplementing WITHOUT deficiency; 8 studies, 0 RCT, speech directly measured in 8)
  • PMID:41854993 — Emerging Discussions on Folinic Acid and Acetaminophen in Autism. (2026)
  • PMID:42662924 — Cerebral folate deficiency, developmental difficulties in autism spect (2026)
  • PMID:23778583 — Redox metabolism abnormalities in autistic children associated with mi (2013)
  • PMID:37864660 — Biological Pathways Associated with Vitamins in Autism Spectrum Disord (2023) calcium — grade C (Association only; 3 studies, 0 RCT, speech directly measured in 3)
  • PMID:36769671 — Associations between Elemental Metabolic Dynamics and Default Mode Net (2023)
  • PMID:20441769 — Mitochondrial dysfunction in autism spectrum disorders: cause or effec (2010)
  • PMID:21766041 — Alterations of GABAergic signaling in autism spectrum disorders. (2011) carnitine — grade C (Supplementing WITHOUT deficiency; 1 studies, 1 RCT, speech directly measured in 1)
  • PMID:29562612 — Comprehensive Nutritional and Dietary Intervention for Autism Spectrum (2018) vitamin A — grade C (Supplementing WITHOUT deficiency; 3 studies, 0 RCT, speech directly measured in 3)
  • PMID:21729335 — Autism. (2010)
  • PMID:19450315 — Autism. (2008)
  • PMID:37055789 — The association of vitamin A, zinc and copper levels with clinical sym (2023) iodine — grade C (Supplementing WITHOUT deficiency; 1 studies, 1 RCT, speech directly measured in 1)
  • PMID:23759468 — Iodine deficiency, thyroid function and hearing deficit: a review. (2013) amino acids — grade C (Supplementing WITHOUT deficiency; 3 studies, 0 RCT, speech directly measured in 3)
  • PMID:37864660 — Biological Pathways Associated with Vitamins in Autism Spectrum Disord (2023)
  • PMID:31551836 — Untargeted Metabolomics for Autism Spectrum Disorders: Current Status (2019)
  • PMID:34442428 — The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Dis (2021)

WEAK EVIDENCE

zinc — grade D (Supplementing WITHOUT deficiency; 1 studies, 0 RCT, speech directly measured in 1)

  • PMID:27824638 — Autism Spectrum Disorder and Avoidant/Restrictive Food Intake Disorder (2017) copper — grade D (Association only; 1 studies, 0 RCT, speech directly measured in 1)
  • PMID:23882147 — Plasma copper and zinc concentration in individuals with autism correl (2012) selenium — grade D (Association only; 1 studies, 0 RCT, speech directly measured in 1)
  • PMID:23118818 — Toxic Metals and Essential Elements in Hair and Severity of Symptoms a (2012)

INSUFFICIENT / NEGATIVE EVIDENCE

None at this level.

ONGOING CLINICAL TRIALS

  • NCT01816178 — Using a Voice Output Communication Aid to Facilitate Language Development in You | status=COMPLETED; ages 2 Years–5 Years; enrollment 5; interventions: :
  • NCT02291172 — Comprehensive Communication Intervention for Minimally Verbal Children With Auti | status=COMPLETED; ages 36 Months–54 Months; enrollment 74; interventions: :
  • NCT02700074 — Brain Mechanisms for Language Processing in Adolescents With Autism Spectrum Dis | status=COMPLETED; ages 14 Years–21 Years; enrollment 88; interventions: :
  • NCT02708290 — Mental Imagery Therapy for Autism (MITA) - an Early Intervention Computerized La | status=COMPLETED; ages 2 Years–12 Years; enrollment 6454; interventions: :
  • NCT02839915 — Leucovorin for the Treatment of Language Impairment in Children With Autism Spec | status=ACTIVE_NOT_RECRUITING; ages 5 Years–17 Years; enrollment 56; interventions: :; :
  • NCT03427138 — Training Early Social Language in Autism | status=TERMINATED; ages 18 Months–59 Months; enrollment 89; interventions: :; :
  • NCT03525951 — Parent-Level Predictors of Early Language Interaction Quality and Intervention O | status=COMPLETED; ages 30 Months–; enrollment 156; interventions: :; :
  • NCT03757585 — Natural Treatments for the Management of Emotional Dysregulation in Youth With N | status=COMPLETED; ages 5 Years–17 Years; enrollment 54; interventions: :; :
  • NCT04060017 — Early Treatment of Language Impairment in Young Children With Autism Spectrum Di | status=ACTIVE_NOT_RECRUITING; ages 30 Months–60 Months; enrollment 80; interventions: :; :
  • NCT04060030 — Treatment of Social and Language Deficits With Leucovorin for Young Children Wit | status=RECRUITING; ages 30 Months–60 Months; enrollment 80; interventions: :; :
  • NCT04218331 — Boosting Language Outcomes of Minimally Verbal Children With ASD (BLOOM) | status=ACTIVE_NOT_RECRUITING; ages 42 Months–66 Months; enrollment 56; interventions: :; :
  • NCT04473729 — Improving Perception of Speech in Noise in Children With Communication Disorders | status=COMPLETED; ages 8 Years–12 Years; enrollment 30; interventions: :
  • NCT04675580 — Telehealth Language Intervention for Children With Autism Ages 2-4 Years | status=COMPLETED; ages 2 Years–4 Years; enrollment 14; interventions: :
  • NCT04764539 — Video Assisted Speech Technology to Enhance Motor Planning for Speech | status=COMPLETED; ages 4 Years–8 Years; enrollment 6; interventions: :
  • NCT05013164 — Role of Folinic Acid in Improving the Adaptive Skills and Language Impairment in | status=COMPLETED; ages 3 Years–14 Years; enrollment 44; interventions: :

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