Speech research — leaderboards
AUTISM SUPPLEMENT EVIDENCE LEADERBOARD
Best grade per intervention across speech/language outcomes (all tracks)
| # | Intervention | Grade | Human studies | RCTs | Speech-direct | Participants | Age range | Largest trial | Safety flag |
|---|---|---|---|---|---|---|---|---|---|
| 1 | folinic acid | B | 15 | 4 | 15 | 0 | 0-8y | n/a | — |
| 2 | essential fatty acids | B | 16 | 3 | 16 | 0 | n/a | n/a | — |
| 3 | vitamin B6 | B | 12 | 1 | 12 | 0 | 1-18y | n/a | YES |
| 4 | iron | B | 11 | 1 | 11 | 0 | 0-49y | n/a | YES |
| 5 | vitamin D | B | 11 | 1 | 11 | 0 | 1-18y | n/a | YES |
| 6 | magnesium | B | 11 | 1 | 11 | 0 | 3-12y | n/a | YES |
| 7 | carnitine | C | 5 | 1 | 5 | 0 | 2-12y | n/a | — |
| 8 | iodine | C | 3 | 1 | 3 | 0 | 3-9y | n/a | YES |
| 9 | folate | C | 26 | 0 | 26 | 0 | 0-49y | n/a | — |
| 10 | vitamin B12 | C | 19 | 0 | 19 | 0 | 0-18y | n/a | — |
| 11 | calcium | C | 11 | 0 | 11 | 0 | 3-12y | n/a | YES |
| 12 | amino acids | C | 6 | 0 | 6 | 0 | 2-12y | n/a | — |
| 13 | vitamin A | C | 5 | 0 | 5 | 0 | 0-49y | n/a | YES |
| 14 | zinc | D | 11 | 0 | 11 | 0 | 0-49y | n/a | YES |
| 15 | copper | D | 5 | 0 | 5 | 0 | 0-15y | n/a | YES |
| 16 | selenium | D | 1 | 0 | 1 | 0 | 3-14y | n/a | YES |
Ranking: evidence grade, then RCT count, then study count. Popularity never ranked.
SLEEP EVIDENCE LEADERBOARD
Interventions/deficiencies studied for sleep outcomes
| # | Intervention | Grade | Human studies | RCTs | Speech-direct | Participants | Age range | Largest trial | Safety flag |
|---|---|---|---|---|---|---|---|---|---|
| 1 | iron | C | 15 | 0 | — | 0 | 0-49y | n/a | YES |
| 2 | vitamin B12 | C | 8 | 0 | — | 0 | 0-18y | n/a | — |
| 3 | vitamin D | C | 7 | 0 | — | 0 | 1-18y | n/a | YES |
| 4 | folate | C | 5 | 0 | — | 0 | 0-49y | n/a | — |
| 5 | copper | C | 3 | 0 | — | 0 | 0-15y | n/a | YES |
| 6 | carnitine | D | 5 | 0 | — | 0 | 2-12y | n/a | — |
| 7 | vitamin B6 | D | 4 | 0 | — | 0 | 1-18y | n/a | YES |
| 8 | essential fatty acids | D | 4 | 0 | — | 0 | n/a | n/a | — |
| 9 | amino acids | D | 4 | 0 | — | 0 | 2-12y | n/a | — |
| 10 | zinc | D | 3 | 0 | — | 0 | 0-49y | n/a | YES |
| 11 | selenium | D | 3 | 0 | — | 0 | 3-14y | n/a | YES |
| 12 | magnesium | D | 2 | 0 | — | 0 | 3-12y | n/a | YES |
| 13 | calcium | D | 2 | 0 | — | 0 | 3-12y | n/a | YES |
| 14 | vitamin A | D | 2 | 0 | — | 0 | 0-49y | n/a | YES |
| 15 | folinic acid | D | 1 | 0 | — | 0 | 0-8y | n/a | — |
| 16 | iodine | D | 1 | 0 | — | 0 | 3-9y | n/a | YES |
Ranking: evidence grade, then RCT count, then study count. Popularity never ranked.
GI / MICROBIOME EVIDENCE LEADERBOARD
Interventions studied for GI outcomes
| # | Intervention | Grade | Human studies | RCTs | Speech-direct | Participants | Age range | Largest trial | Safety flag |
|---|---|---|---|---|---|---|---|---|---|
| 1 | zinc | B | 21 | 1 | — | 0 | 0-49y | n/a | YES |
| 2 | folate | B | 12 | 1 | — | 0 | 0-49y | n/a | — |
| 3 | iodine | B | 3 | 1 | — | 0 | 3-9y | n/a | YES |
| 4 | iron | C | 20 | 0 | — | 0 | 0-49y | n/a | YES |
| 5 | vitamin A | C | 17 | 0 | — | 0 | 0-49y | n/a | YES |
| 6 | essential fatty acids | C | 15 | 0 | — | 0 | n/a | n/a | — |
| 7 | vitamin B12 | C | 11 | 0 | — | 0 | 0-18y | n/a | — |
| 8 | vitamin D | C | 9 | 0 | — | 0 | 1-18y | n/a | YES |
| 9 | calcium | C | 7 | 0 | — | 0 | 3-12y | n/a | YES |
| 10 | carnitine | C | 7 | 0 | — | 0 | 2-12y | n/a | — |
| 11 | vitamin B6 | C | 6 | 0 | — | 0 | 1-18y | n/a | YES |
| 12 | amino acids | C | 5 | 0 | — | 0 | 2-12y | n/a | — |
| 13 | magnesium | C | 4 | 0 | — | 0 | 3-12y | n/a | YES |
| 14 | copper | D | 2 | 0 | — | 0 | 0-15y | n/a | YES |
| 15 | vitamin E | D | 2 | 0 | — | 0 | 1-18y | n/a | YES |
| 16 | folinic acid | D | 1 | 0 | — | 0 | 0-8y | n/a | — |
| 17 | selenium | D | 1 | 0 | — | 0 | 3-14y | n/a | YES |
Ranking: evidence grade, then RCT count, then study count. Popularity never ranked.
DEFICIENCY CORRECTION EVIDENCE LEADERBOARD
Track A only: correcting CONFIRMED deficiency -> functional outcome
| # | Intervention | Grade | Human studies | RCTs | Speech-direct | Participants | Age range | Largest trial | Safety flag |
|---|---|---|---|---|---|---|---|---|---|
| 1 | folate | C | 6 | 1 | 0 | 0 | 0-49y | n/a | — |
| 2 | folinic acid | C | 4 | 1 | 0 | 0 | 0-8y | n/a | — |
| 3 | calcium | C | 3 | 1 | 1 | 0 | 3-12y | n/a | YES |
| 4 | iron | C | 16 | 0 | 4 | 0 | 0-49y | n/a | YES |
| 5 | essential fatty acids | C | 8 | 0 | 1 | 0 | n/a | n/a | — |
| 6 | vitamin B12 | D | 9 | 0 | 1 | 0 | 0-18y | n/a | — |
| 7 | vitamin D | D | 4 | 0 | 0 | 0 | 1-18y | n/a | YES |
| 8 | zinc | D | 2 | 0 | 0 | 0 | 0-49y | n/a | YES |
| 9 | copper | D | 2 | 0 | 0 | 0 | 0-15y | n/a | YES |
| 10 | selenium | D | 1 | 0 | 0 | 0 | 3-14y | n/a | YES |
| 11 | carnitine | D | 1 | 0 | 0 | 0 | 2-12y | n/a | — |
Ranking: evidence grade, then RCT count, then study count. Popularity never ranked.
MOST STUDIED INTERVENTIONS
By total human studies
| # | Intervention | Grade | Human studies | RCTs | Speech-direct | Participants | Age range | Largest trial | Safety flag |
|---|---|---|---|---|---|---|---|---|---|
| 1 | iron | A | 162 | 9 | 11 | 0 | 0-49y | n/a | YES |
| 2 | iodine | A | 55 | 7 | 3 | 0 | 3-9y | n/a | YES |
| 3 | folinic acid | B | 40 | 9 | 15 | 0 | 0-8y | n/a | — |
| 4 | essential fatty acids | B | 108 | 8 | 16 | 0 | n/a | n/a | — |
| 5 | folate | B | 122 | 7 | 26 | 0 | 0-49y | n/a | — |
| 6 | magnesium | B | 58 | 7 | 11 | 0 | 3-12y | n/a | YES |
| 7 | vitamin B6 | B | 57 | 6 | 12 | 0 | 1-18y | n/a | YES |
| 8 | zinc | B | 99 | 5 | 11 | 0 | 0-49y | n/a | YES |
| 9 | carnitine | B | 47 | 5 | 5 | 0 | 2-12y | n/a | — |
| 10 | vitamin D | B | 99 | 4 | 11 | 0 | 1-18y | n/a | YES |
| 11 | amino acids | B | 45 | 2 | 6 | 0 | 2-12y | n/a | — |
| 12 | vitamin B12 | B | 105 | 1 | 19 | 0 | 0-18y | n/a | — |
| 13 | copper | B | 37 | 1 | 5 | 0 | 0-15y | n/a | YES |
| 14 | selenium | B | 19 | 1 | 1 | 0 | 3-14y | n/a | YES |
| 15 | calcium | C | 43 | 1 | 11 | 0 | 3-12y | n/a | YES |
| 16 | vitamin A | C | 51 | 0 | 5 | 0 | 0-49y | n/a | YES |
| 17 | vitamin E | D | 10 | 0 | 0 | 0 | 1-18y | n/a | YES |
| 18 | probiotics | D | 2 | 0 | 0 | 0 | n/a | n/a | — |
Ranking: evidence grade, then RCT count, then study count. Popularity never ranked.
MOST PROMISING BUT PRELIMINARY
Grade C — worth watching, not established
| # | Intervention | Grade | Human studies | RCTs | Speech-direct | Participants | Age range | Largest trial | Safety flag |
|---|---|---|---|---|---|---|---|---|---|
| 1 | carnitine | C | 5 | 1 | 5 | 0 | 2-12y | n/a | — |
| 2 | iodine | C | 3 | 1 | 3 | 0 | 3-9y | n/a | YES |
| 3 | folate | C | 26 | 0 | 26 | 0 | 0-49y | n/a | — |
| 4 | vitamin B12 | C | 19 | 0 | 19 | 0 | 0-18y | n/a | — |
| 5 | calcium | C | 11 | 0 | 11 | 0 | 3-12y | n/a | YES |
| 6 | amino acids | C | 6 | 0 | 6 | 0 | 2-12y | n/a | — |
| 7 | vitamin A | C | 5 | 0 | 5 | 0 | 0-49y | n/a | YES |
Ranking: evidence grade, then RCT count, then study count. Popularity never ranked.
NEGATIVE OR CONFLICTING EVIDENCE
Weak grades despite substantial study — evidence did not hold up
| # | Intervention | Grade | Human studies | RCTs | Speech-direct | Participants | Age range | Largest trial | Safety flag |
|---|---|---|---|---|---|---|---|---|---|
| 1 | zinc | D | 11 | 0 | 11 | 0 | 0-49y | n/a | YES |
| 2 | copper | D | 5 | 0 | 5 | 0 | 0-15y | n/a | YES |
Ranking: evidence grade, then RCT count, then study count. Popularity never ranked.
INTERVENTIONS WITH IMPORTANT SAFETY CONCERNS
Excess-intake harm flags; supplementation without deficiency not supported
| # | Intervention | Grade | Human studies | RCTs | Speech-direct | Participants | Age range | Largest trial | Safety flag |
|---|---|---|---|---|---|---|---|---|---|
| 1 | iron | A | 162 | 9 | 11 | 0 | 0-49y | n/a | YES |
| 2 | iodine | A | 55 | 7 | 3 | 0 | 3-9y | n/a | YES |
| 3 | magnesium | B | 58 | 7 | 11 | 0 | 3-12y | n/a | YES |
| 4 | vitamin B6 | B | 57 | 6 | 12 | 0 | 1-18y | n/a | YES |
| 5 | zinc | B | 99 | 5 | 11 | 0 | 0-49y | n/a | YES |
| 6 | vitamin D | B | 99 | 4 | 11 | 0 | 1-18y | n/a | YES |
| 7 | copper | B | 37 | 1 | 5 | 0 | 0-15y | n/a | YES |
| 8 | selenium | B | 19 | 1 | 1 | 0 | 3-14y | n/a | YES |
| 9 | calcium | C | 43 | 1 | 11 | 0 | 3-12y | n/a | YES |
| 10 | vitamin A | C | 51 | 0 | 5 | 0 | 0-49y | n/a | YES |
| 11 | vitamin E | D | 10 | 0 | 0 | 0 | 1-18y | n/a | YES |
Ranking: evidence grade, then RCT count, then study count. Popularity never ranked.